Missouri sacked Colorado quarterback Tyler Hansen eight times and forced four turnovers, racing out to a 33-0 lead en route to a 36-17 victory. The Buffs out-scored the Tigers 14-0 in the third quarter to make it interesting, but four possessions with the score 33-17 netted two turnovers on downs, an interception, and a punt, as Colorado fell to 2-6, 1-3 on the season. A homecoming crowd of 45,634, the smallest crowd of the season, was on hand to witness a fourth straight win for Missouri in the series.

Missouri had out-scored Colorado 113-10 the past two seasons, and, in the first half of the 2009 game, it appeared as if the scores of 55-10 and 58-0 were mere preludes to the hurt the Tigers were going to put on the Buffs in 2009. The Tigers took the opening kickoff, and smartly marched 80 yards down the field. The Colorado defense did force two third downs – 3rd-and-two at the Missouri 28 yard line, and third-and-nine at the Missouri 47, giving Buff fans hope (after all, Colorado was ranked 19th in the nation in 3rd-down defense, at 32%; and was even better at Folsom) – but Missouri easily converted both chances. An 11-play drive was capped off by a one-yard run by Derrick Washington 4:27 into the game.