For the second time in 2009, Colorado held a 14-10 halftime lead, on the road, against a ranked conference opponent. As with the Texas game in October, however, the Buffs could not hold the lead, falling 31-28 to No. 12 Oklahoma State. The Buffs turned four Cowboy turnovers and the poor play of backup quarterbacks into a 21-10 lead, but were unable to come away with their first road victory since 2007.

Four 15-yard penalties, missed opportunities, and a complete lack of a running game dropped the Buffs to a 3-8 season record. Oklahoma State did not complete a pass in the first half, as backup quarterback Alan Cote, substituting for the injured Zac Robinson, started 0-for-9 with an interception. Turning to third-string quarterback Brandon Weeden, the Cowboys found the spark they were looking for. Weeden went 10-for-15 for 168 yards and two touchdowns in leading the second half comeback. Colorado also played two quarterbacks, with starter Tyler Hansen missing much of the second quarter with a hand injury. Cody Hawkins was mostly effective in relief, going 7-for-11 for 69 yards, including a five-yard touchdown pass to Riar Geer just before halftime.